Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar;111(3):174-80.
doi: 10.1590/0074-02760150367. Epub 2016 Mar 15.

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Erinaldo Ubirajara Damasceno dos Santos  1 , Géssica Dayane Cordeiro de Lima  2 , Micheline de Lucena Oliveira  3 , Sandra de Andrade Heráclio  4 , Hildson Dornelas Angelo da Silva  5 , Sergio Crovella  6 , Maria de Mascena Diniz Maia  1 , Paulo Roberto Eleutério de Souza  1
Affiliations

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

Erinaldo Ubirajara Damasceno dos Santos et al. Mem Inst Oswaldo Cruz. 2016 Mar.

Abstract

Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.

PubMed Disclaimer

References

    1. Ahmadabadi BN, Hassanshahi G, Khoramdelazad H, Mirzaei V, Sajadi SM, Hajghani M, Khodadadi H, Pourali R, Arababadi MK, Kennedy D. Downregulation of CCR5 expression on the peripheral blood CD8+ T-cells of South-Eastern Iranian patients with chronic hepatitis B infection. Inflammation. 2012;36:136–140. - PubMed
    1. Al-Abdulhadi SA, Al-Rabia MW. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. Ann Saudi Med. 2010;30:115–122. - PMC - PubMed
    1. Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 co-receptors: roles in viral entry, tropism, and disease. Annu Rev Immunol. 1999;17:657–700. - PubMed
    1. Bernard HU, Burk RD, Chen Z, Van Doorslaer K, Hausen H, Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology. 2010;401:70–79. - PMC - PubMed
    1. Bonanni P, Bechini A, Donato R, Capei R, Sacco C, Leviand M, Boccalini S. Human papilloma virus vaccination: impact and recommendations across the world. Ther Adv Vaccines. 2015;3:3–12. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources