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Randomized Controlled Trial
. 2016 Apr;11(3):133-7.
doi: 10.1089/bfm.2015.0166. Epub 2016 Mar 16.

Premature Infants 750-1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner

Amy B Hair  1 , Erynn M Bergner  1 , Martin L Lee  2 , Alvaro G Moreira  3 , Keli M Hawthorne  4 , David J Rechtman  2 , Steven A Abrams  4 , Cynthia L Blanco  3
Affiliations
Randomized Controlled Trial

Premature Infants 750-1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner

Amy B Hair et al. Breastfeed Med. 2016 Apr.

Abstract

Objective: Infants may benefit from early nutritional intervention to decrease hospital stay. To evaluate the effects of adding a human milk (HM)-derived cream (Cream) product to a standard feeding regimen in preterm infants.

Materials and methods: In a prospective multicenter randomized study, infants with birth weights 750-1,250 g were assigned to a Control or Cream group. The Control group received a standard feeding regimen consisting of mother's own milk or donor HM with donor HM-derived fortifier. The Cream group received the standard feeding regimen along with an additional HM-derived cream supplement when the HM they received was <20 kcal/oz. Primary outcomes of this secondary analysis included comorbidities, length of stay (LOS), and postmenstrual age (PMA) at discharge.

Results: We enrolled 75 infants (Control n = 37, Cream n = 38) with gestational age 27.7 ± 1.8 weeks and birth weight 973 ± 145 g (mean ± SD). After adjusting for gestational age, birth weight, and presence of bronchopulmonary dysplasia (BPD), the Cream group had a decreased PMA at discharge (39.9 ± 4.8 versus 38.2 ± 2.7 weeks, p = 0.03) and LOS (86 ± 39 versus 74 ± 22 days, p = 0.05). For 21 infants with BPD, these values trended toward significance for PMA at discharge (44.2 ± 6.1 versus 41.3 ± 2.7 weeks, p = 0.08) and LOS (121 ± 49 versus 104 ± 23 days, p = 0.08).

Conclusions: Very preterm infants who received an HM-derived cream supplement were discharged earlier. Infants with BPD may have benefited the most.

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References

    1. Schanler RJ. Outcomes of human milk-fed premature infants. Semin Perinatol 2011;35:29–33 - PubMed
    1. Sullivan S, Schanler RJ, Kim JH, et al. . An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr 2010;156:562–567 - PubMed
    1. Cristofalo EA, Schanler RJ, Blanco CL, et al. . Randomized trial of exclusive human milk versus preterm formula diets in extremely premature infants. J Pediatr 2013;163:1592–1595 - PubMed
    1. Abrams SA, Schanler RJ, Lee ML, et al. . Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products. Breastfeed Med 2014;9:281–285 - PMC - PubMed
    1. American Academy of Pediatrics Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2012;129:e827–e841 - PubMed

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