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Review
. 2016 Mar 16:20:68.
doi: 10.1186/s13054-016-1222-8.

Metabonomics and intensive care

Affiliations
Review

Metabonomics and intensive care

David Antcliffe et al. Crit Care. .

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.

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Figures

Fig. 1
Fig. 1
Schematic diagram detailing the main components of a nuclear magnetic resonance (NMR) spectrometer
Fig. 2
Fig. 2
Example of a 1H nuclear magnetic resonance Carr‐Purcell‐Meiboom‐Gill (NMR CPMG) spectrum of human serum. TSP: 3‐(trimethyl‐silyl) propionic acid
Fig. 3
Fig. 3
A schematic diagram of the component parts of a mass spectrometer
Fig. 4
Fig. 4
Demonstration of how a multivariate set of data (a) is converted into a principal component analysis (PCA) scores plot (b) by detecting the directions of greatest variation and converting these into a new set of axes. The circle represents Hotelling’s ellipse

References

    1. Holmes E, Wilson ID, Nicholson JK. Metabolic phenotyping in health and disease. Cell. 2008;134:714–717. doi: 10.1016/j.cell.2008.08.026. - DOI - PubMed
    1. Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455:1054–1056. doi: 10.1038/4551054a. - DOI - PubMed
    1. Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002;1:153–161. doi: 10.1038/nrd728. - DOI - PubMed
    1. Nicholson JK, Lindon JC. Systems biology – metabonomics. Nature. 2008;455:1054–1056. doi: 10.1038/4551054a. - DOI - PubMed
    1. Beckonert O, Keun HC, Ebbels TM, et al. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007;2:2692–2703. doi: 10.1038/nprot.2007.376. - DOI - PubMed

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