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. 2016 Apr;11(1):53-8.
doi: 10.1007/s11751-016-0251-9. Epub 2016 Mar 16.

The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union

Madhavan C Papanna  1 , K A Saldanha  2 , Binu Kurian  2 , James A Fernandes  2 , Stan Jones  2
Affiliations

The use of recombinant morphogenic protein-2(rhBMP-2) in children undergoing revision surgery for persistent non-union

Madhavan C Papanna et al. Strategies Trauma Limb Reconstr. 2016 Apr.

Abstract

The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4-15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application. Patients had undergone a mean of 2 (1-5) operations prior to implantation of rhBMP-2. All the patients in the study group were available for review with mean follow-up of 44 months (range 21-70). The mean time to union was 16 weeks (range 10-28 weeks). No adverse events related to BMP-2 application were noted in our study group. Healing occurred clinically and radiographically in 16 of the 17 sites. Our study demonstrates that BMP-2 enhances healing of the persistent non-unions without any adverse events.

Keywords: Bone; Congenital abnormalities non-union; rhBMP-2.

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Figures

Fig. 1
Fig. 1
This 12-year-old patient with congenital pseudoarthrosis of the tibia had multiple surgical procedures to enhance the healing of non-union. a Preoperative radiograph showing the non-union of the pseudoarthrosis with growing rod in situ. b Intraoperative images illustrating the revision intramedullary nailing and BMP-2 insertion. c Anteroposterior view radiograph at 14 weeks after initial surgery showing healing at the pseudoarthrosis site
See this image and copyright information in PMC

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