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Review
. 2016 May;364(2):225-9.
doi: 10.1007/s00441-016-2387-9. Epub 2016 Mar 17.

The role of IL-1β in Pseudomonas aeruginosa in lung infection

B Wonnenberg  1 , M Bischoff  2 , C Beisswenger  3 , T Dinh  4 , R Bals  3 , B Singh  5 , T Tschernig  6
Affiliations
Review

The role of IL-1β in Pseudomonas aeruginosa in lung infection

B Wonnenberg et al. Cell Tissue Res. 2016 May.

Abstract

This mini-review examines the role of the pro-inflammatory cytokine interleukin (IL)-1β in the interaction of Pseudomonas aeruginosa and the host immune system during lung infection. Different studies show that the reduction of the inflammatory response, especially a decrease in IL-1β, leads to a better outcome in acute lung infection with this bacterium. This includes a higher survival rate, reduced damage to the lung tissue and, in particular, a better clearance of the airways and the tissue of the lungs from P. aeruginosa.

Keywords: IL-1β; Inflammasomes; Inflammation; Pneumonia; Pseudomonas aeruginosa.

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