Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar 1;32(1):58-66.
doi: 10.5152/UCD.2015.3032. eCollection 2016.

Primary hyperparathyroidism

Tarıq Madkhali  1 , Amal Alhefdhi  1 , Herbert Chen  1 , Dawn Elfenbein  1
Affiliations
Review

Primary hyperparathyroidism

Tarıq Madkhali et al. Ulus Cerrahi Derg. .

Abstract

Primary hyperparathyroidism is a common endocrine disorder caused by overactivation of parathyroid glands resulting in excessive release of parathyroid hormone. The resultant hypercalcemia leads to a myriad of symptoms. Primary hyperparathyroidism may increase a patient's morbidity and even mortality if left untreated. During the last few decades, disease presentation has shifted from the classic presentation of severe bone and kidney manifestations to most patients now being diagnosed on routine labs. Although surgery is the only curative therapy, many advances have been made over the past decades in the diagnosis and the surgical management of primary hyperparathyroidism. The aim of this review is to summarize the characteristics of the disease, the work up, and the treatment options.

Keywords: Primary hyperparathyroidism; parathyroid hormone; parathyroidectomy.

PubMed Disclaimer

References

    1. Carneiro-Pla DM, Irvin GL, 3rd, Chen H. Consequences of parathyroidectomy in patients with “mild” sporadic primary hyperparathyroidism. Surgery. 2007;142:795–799. http://dx.doi.org/10.1016/j.surg.2007.09.019. - DOI - PubMed
    1. Gopinath P, Mihai R. Hyperparathyroidism. Surgery. 2011;29:451–458. http://dx.doi.org/10.1016/j.mpsur.2011.06.015. - DOI
    1. Cordellat IM. Hyperparathyroidism: primary or secondary disease? Rheumatol Clin. 2012;8:287–291. - PubMed
    1. Conrad DN, Olson JE, Hartwig HM, Mack E, Chen H. A prospective evaluation of novel methods to intraoperatively distinguish parathyroid tissue utilizing a parathyroid hormone assay. J Surg Res. 2006;133:38–41. http://dx.doi.org/10.1016/j.jss.2006.02.029. - DOI - PubMed
    1. Westin G, Bjorklund P, Akerstrom G. Molecular genetics of parathyroid disease. World J Surg. 2009;33:2224–2233. http://dx.doi.org/10.1007/s00268-009-0022-6. - DOI - PubMed