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Review
. 2016 Apr:17:104-109.
doi: 10.1016/j.coviro.2016.02.010. Epub 2016 Mar 15.

Approaches to preventative and therapeutic HIV vaccines

Glenda E Gray  1 , Fatima Laher  2 , Erica Lazarus  2 , Barbara Ensoli  3 , Lawrence Corey  4
Affiliations
Review

Approaches to preventative and therapeutic HIV vaccines

Glenda E Gray et al. Curr Opin Virol. 2016 Apr.

Abstract

Novel strategies are being researched to discover vaccines to prevent and treat HIV-1. Non-efficacious preventative vaccine approaches include bivalent recombinant gp120 alone, HIV gene insertion into an Adenovirus 5 (Ad5) virus vector and the DNA prime/Ad5 boost vaccine regimen. However, the ALVAC-HIV prime/AIDSVAX® B/E gp120 boost regimen showed 31.2% efficacy at 3.5 years, and is being investigated as clade C constructs with an additional boost. Likewise, although multiple therapeutic vaccines have failed in the past, in a non-placebo controlled trial, a Tat vaccine demonstrated immune cell restoration, reduction of immune activation, and reduced HIV-1 DNA viral load. Monoclonal antibodies for passive immunization or treatment show promise, with VRC01 entering advanced clinical trials.

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Figures

Figure 1
Figure 1
Major advances in the path toward novel vaccine designs
Figure 2
Figure 2
Development pathway to HIV preventative vaccine licensure in South Africa
See this image and copyright information in PMC

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