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. 2016;34(3):148-54.
doi: 10.3109/07357907.2016.1139716. Epub 2016 Mar 17.

Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?

Helen E Dinkelspiel  1 , Cathleen Matrai  2 , Sara Pauk  3 , Alain Pierre-Louis  3 , Ya-Lin Chiu  3 , Divya Gupta  4 , Thomas Caputo  4 , Lora Hedrick Ellenson  2 , Kevin Holcomb  4
Affiliations

Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer?

Helen E Dinkelspiel et al. Cancer Invest. 2016.

Abstract

Ovarian cancers diagnosed between 2000 and 2013 were examined and cases with and without endometriosis compared. Among 139 epithelial ovarian, there were 49 (35%) with endometriosis and 90 (65%) without endometriosis. Endometriosis associated ovarian cancers were more likely to be confined to the pelvis (54% vs. 9%, p < 0.0001) and lower grade (51% vs. 29%, p = 0.014). Younger age and earlier stage independently predicted the presence of endometriosis (p = 0.0011 and p < 0.0001, respectively). Ovarian cancer patients with endometriosis had improved PFS and OS [(HR = 0.20; 95% CI, 0.09-0.43), (HR = 0.18; 95% CI, 0.04-0.81)], compared to patients without endometriosis; however, endometriosis had no independent prognostic significance.

Keywords: Epidemiology; Outcomes research; Outreach; Ovarian cancer.

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Figures

Figure 1
Figure 1
Kaplan-Meier analysis of progression free survival (p<0.0001) of patients with epithelial ovarian cancer stratified by presence of endometriosis versus no endometriosis
Figure 2
Figure 2
Kaplan-Meier analysis of overall survival (p=0.012) of patients with epithelial ovarian cancer stratified by presence of endometriosis versus no endometriosis
Figure 2
Figure 2
Kaplan-Meier analysis of overall survival (p=0.012) of patients with epithelial ovarian cancer stratified by presence of endometriosis versus no endometriosis
See this image and copyright information in PMC

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