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. 2016 Apr 20:224:64-5.
doi: 10.1016/j.jbiotec.2016.03.021. Epub 2016 Mar 14.

Complete genome sequence of 'Mycobacterium neoaurum' NRRL B-3805, an androstenedione (AD) producer for industrial biotransformation of sterols

Antonio Rodríguez-García  1 , Estela Fernández-Alegre  2 , Alejandro Morales  2 , Alberto Sola-Landa  2 , Jess Lorraine  3 , Sandy Macdonald  3 , Dmitry Dovbnya  4 , Margaret C M Smith  3 , Marina Donova  4 , Carlos Barreiro  5
Affiliations

Complete genome sequence of 'Mycobacterium neoaurum' NRRL B-3805, an androstenedione (AD) producer for industrial biotransformation of sterols

Antonio Rodríguez-García et al. J Biotechnol. .

Abstract

Microbial bioconversion of sterols into high value steroid precursors, such as 4-androstene-3,17-dione (AD), is an industrial challenge. Genes and enzymes involved in sterol degradation have been proposed, although the complete pathway is not yet known. The genome sequencing of the AD producer strain 'Mycobacterium neoaurum' NRRL B-3805 (formerly Mycobacterium sp. NRRL B-3805) will serve to elucidate the critical steps for industrial processes and will provide the basis for further genetic engineering. The genome comprises a circular chromosome (5 421 338bp), is devoid of plasmids and contains 4844 protein-coding genes.

Keywords: 4-Androstene-3,17-dione; AD; ADD; Actinobacteria; Genome sequence; Mycobacterium; Steroids.

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