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. 2016 May;6(5):OF12.
doi: 10.1158/2159-8290.CD-RW2016-048. Epub 2016 Mar 17.

A High-Fat Diet Promotes Intestinal Stemness and Tumorigenesis

No authors listed

A High-Fat Diet Promotes Intestinal Stemness and Tumorigenesis

No authors listed. Cancer Discov. 2016 May.

Abstract

A high-fat diet boosts Lgr5(+) intestinal stem cell number and function, enhancing tumor formation.

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  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
    Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH. Beyaz S, et al. Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173. Nature. 2016. PMID: 26935695 Free PMC article.

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