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. 2016 Feb;9(1):24-7.
doi: 10.1159/000442846. Epub 2016 Feb 10.

Can the Free/Total PSA Ratio Predict the Gleason Score Before Prostate Biopsy?

Cavit Ceylan  1 , Eymen Gazel  1 , İbrahim Keleş  2 , Ömer Doluoğlu  3 , Metin Yığman  1
Affiliations

Can the Free/Total PSA Ratio Predict the Gleason Score Before Prostate Biopsy?

Cavit Ceylan et al. Curr Urol. 2016 Feb.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Curr Urol. 2016 Oct;9(3):162. doi: 10.1159/000452641. Epub 2016 Oct 18. Curr Urol. 2016. PMID: 27867336 Free PMC article.

Abstract

Objectives: To determine whether there is a correlation between high Gleason score and free/total (f/t) prostate specific antigen (PSA) in patients newly diagnosed with prostate carcinoma.

Materials and methods: The study included 272 prostate biopsy patients whose total PSA value ranged from 4-10 ng/ml. The patients were divided into 2 groups according to the f/t PSA ratio: Group 1 ≤ 15% and Group 2 > 15%. Furthermore, the groups were also compared to each other in terms of mild (≤ 6), moderate (= 7), and high (≥ 8) Gleason score.

Results: Group 1 consisted of 135 (49.6%) patients and Group 2 consisted of 137 (50.4%) patients. While 27 (20%) patients had a high Gleason score in Group 1, only 10 (7.3%) patients had a high Gleason score in Group 2 (p = 0.008). Using Spearman's correlation test, we found that the f/t PSA ratios were observed to decrease significantly in all patients with increased Gleason scores (p = 0.002, r = -0.185).

Conclusion: According to our study, there is a relationship between higher Gleason score and decreased f/t PSA ratio. Therefore, f/t PSA can be an indicator for predicting the Gleason score.

Keywords: Gleason score; PSA; Percent free PSA prostate cancer; Prostate biopsy.

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References

    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29. - PubMed
    1. Arnold M, Karim-Kos HE, Coebergh JW, Byrnes G, Antilla A, Ferlay J, Renehan AG, Forman D, Soerjomataram I. Recent trends in incidence of five common cancers in 26 European countries since 1988: analysis of the European Cancer Observatory. Eur J Cancer. 2015;51:1164–1187. - PubMed
    1. Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, Mason M, Matveev V, Wiegel T, Zattoni F, Mottet N. EAU guidelines on prostate cancer. part 1: screening, diagnosis, and localtreatment with curative intent-update 2013. Eur Urol. 2014;65:124–137. - PubMed
    1. Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJ, Petros JA, Andriole GL. Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991;324:1156–1161. - PubMed
    1. Stenman UH, Hakama M, Knekt P, Aromaa A, Teppo L, Leinonen J. Serum concentrations of prostate specific antigenand its complex with a-1-antichymotrypsin before diagnosis of prostatic cancer. Lancet. 1994;344:1594–1598. - PubMed