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Review
. 2016 Feb;5(1):1-5.
doi: 10.5582/irdr.2015.01047.

Rosai-Dorfman disease and the heart

Kevin O'Gallagher  1 , Luke Dancy  1 , Aish Sinha  1 , Daniel Sado  1
Affiliations
Review

Rosai-Dorfman disease and the heart

Kevin O'Gallagher et al. Intractable Rare Dis Res. 2016 Feb.

Abstract

Rosai-Dorfman disease (RDD) is a non-malignant pathology of histiocyte proliferation. The classical clinical presentation is with painless cervical lymphadenopathy, but extranodal involvement is frequent, occurring in approximately 40% of cases. The literature was systematically reviewed to identify reported cases of RDD with cardiac involvement. Eighteen cases were identified (3 pediatric and 15 adult). In adult cardiac RDD (cRDD), three patterns of disease were noted: an intra-cardiac mass, epicardial involvement, and pulmonary artery involvement. Reported cases suggest that surgical excision of intra-cardiac masses confers a good prognosis.

Keywords: Histiocytosis; cardiac; non-Langerhans.

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Figures

Figure 1.
Figure 1.
Patterns of cardiac involvement in adults with Rosai-Dorfman disease.
See this image and copyright information in PMC

References

    1. Destombes P. Adenitis with lipid excess, in children or young adults, seen in the Antilles and in Mali (4 cases). Bull Soc Pathol Exot Filiales. 1965; 58:1035-1039. (in French) - PubMed
    1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol. 1969; 87:63-70. - PubMed
    1. Gaitonde S. Multifocal, extranodal sinus histiocytosis with massive lymphadenopathy: An overview. Arch Pathol Lab Med. 2007; 131:1117-1121. - PubMed
    1. Levine PH, Jahan N, Murari P, Manak M, Jaffe ES. Detection of human herpesvirus 6 in tissue involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). J Infect Dis. 1992; 166:291-295. - PubMed
    1. Ortonne N, Fillet AM, Kosuge H, Bagot M, Frances C, Wechsler J. Cutaneous Destombes-Rosai-Dorfman disease: Absence of detection of HHV-6 and HHV-8 in skin. J Cutan Pathol. 2002; 29:113-118. - PubMed

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