Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 1;5(1):67-73.
doi: 10.15171/jcs.2016.007. eCollection 2016 Mar.

Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial

Seyedeh Zahra Masoumi  1 , Maryam Ataollahi  2 , Khodayar Oshvandi  3
Affiliations

Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial

Seyedeh Zahra Masoumi et al. J Caring Sci. .

Abstract

Introduction: Premenstrual syndrome is one of the most common disorders in women, which includes a group of psychological and physical symptoms. The aim of this study was to examine the impact of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms.

Methods: This double blind randomized controlled was carried out on 76 students of Hamadan University of Medical Sciences. Students were randomly allocated to two groups. (38 people in each group). Student in intervention groups received calcium tablet (500mg) and vitamin B6 (40 mg) and student in intervention groups received only vitamin B6 twice a day for two consecutive months. The symptoms were assessed by Beck depression inventory (BDI) and daily symptom records (DSR) questionnaires. Analyses were carried out by test-retest method, Chi-square, Mann-Whitney, Independent t-test, and paired t-test using SPSS software ver.13. Results The result showed that although the severity of symptoms decreased in both groups, but this reduction was more significant in the combined calcium and vitamin B6 group.

Conclusion: According to the result, using of combination of calcium and vitamin B6 leads to better controlling of the premenstrual syndrome symptoms. Therefore it is recommended for women who suffer from these syndromes.

Keywords: Calcium; Menstrual cycle; Premenstrual syndrome; Vitamin B6.

PubMed Disclaimer

Figures

Figure 1
Figure 1
See this image and copyright information in PMC

References

    1. Cheng SH, Shih CC, Yang YK, Chen KT, Chang YH, Yang YC. Factors associated with premenstrual syndrome—A survey of new female university students. Kaohsiung J Med Sci. 2013;29(2):100–5. doi: 10.1016/j.kjms.2012.08.017. - DOI - PMC - PubMed
    1. Zaka M, Mahmood KT. Pre-menstrual syndrome-a review. Journal of Pharmaceutical Sciences & Research. 2012;4(1):1684–91.
    1. Delaram M, Jafari F. The effect of fennel on the premenstrual syndrome. Knowledge and Health Journal. 2011;6(1):1–6.
    1. Panay N. Management of premenstrual syndrome. J Fam Plann Reprod Health Care. 2009;35(3):187–94. doi: 10.1783/147118909788708147. - DOI - PubMed
    1. Ghanbari Z, Haghollahi F, Shariat M, Foroshani AR, Ashrafi M. Effects of calcium supplement therapy in women with premenstrual syndrome. Taiwan J Obstet Gynecol. 2009;48(2):124–29. doi: 10.1016/S1028-4559(09)60271-0. - DOI - PubMed

LinkOut - more resources