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Comment
. 2016 Mar 17;61(6):793-4.
doi: 10.1016/j.molcel.2016.03.002.

Rewiring Cas9 to Target New PAM Sequences

Virginijus Siksnys  1 , Giedrius Gasiunas  2
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Rewiring Cas9 to Target New PAM Sequences

Virginijus Siksnys et al. Mol Cell. .
Free article

Abstract

Papers by Anders et al. (2016) and Hirano et al. (2016b), published in this issue of Molecular Cell, show that SpCas9 uses an induced fit mechanism to recognize altered protospacer adjacent motif (PAM) sequences.

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