Comment
doi: 10.1016/j.molcel.2016.03.003.
An Acetyldegron Triggers CRBN to Take Down the "Q"
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- PMID: 26990985
- DOI: 10.1016/j.molcel.2016.03.003
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An Acetyldegron Triggers CRBN to Take Down the "Q"
Mol Cell.
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Free article
Abstract
In this issue of Molecular Cell, Nguyen et al. (2016) show that p300/CBP-mediated acetylation of glutamine synthetase (GS) triggers recognition by the CRL4(CRBN) E3 ubiquitin ligase, resulting in its ubiquitylation and degradation in response to high glutamine concentrations.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.Mol Cell. 2016 Mar 17;61(6):809-20. doi: 10.1016/j.molcel.2016.02.032. Mol Cell. 2016. PMID: 26990986 Free PMC article.
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