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Case Reports
. 2016 May:78:66-70.
doi: 10.1016/j.jcv.2016.03.010. Epub 2016 Mar 9.

Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing

Masanori Sato  1 , Makoto Kuroda  2 , Masashi Kasai  3 , Hikoro Matsui  3 , Tetsuhiro Fukuyama  4 , Harutaka Katano  5 , Keiko Tanaka-Taya  6
Affiliations
Case Reports

Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing

Masanori Sato et al. J Clin Virol. 2016 May.

Abstract

We report a case of an immunodeficient 4-year-old boy with acute encephalopathy possibly related to human astrovirus-MLB1 infection. The astrovirus-MLB1 genome was identified in his stool, serum, cerebrospinal fluid, urine, and throat swabs by next generation sequencing. We present additional evidence showing human astroviruses are important infectious agents, regardless of their clades, involving the central nervous system in immunocompromised hosts.

Keywords: Astrovirus MLB1; Encephalopathy; Immunodeficiency; Next generation sequencing.

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