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Review
. 2016 May;173(4):545-59.
doi: 10.1111/bjh.14017. Epub 2016 Mar 15.

Current status and future directions of T-lymphoblastic lymphoma in children and adolescents

Birgit Burkhardt  1 , Stephanie Mueller  1 , Tasneem Khanam  1 , Sherrie L Perkins  2
Affiliations
Review

Current status and future directions of T-lymphoblastic lymphoma in children and adolescents

Birgit Burkhardt et al. Br J Haematol. 2016 May.

Abstract

The main challenges in the treatment of T-cell lymphoblastic lymphoma (T-LBL) in children and adolescents are twofold: to increase survival rates in concert with reduction of acute and long-term toxicities including the rate of secondary malignancies. The need for molecular and prognostic markers in T-LBL is crucial to allow for systematic treatment optimization and may serve as targets for new treatment approaches.

Keywords: Paediatric T-lymphoblastic lymphoma; genetic classifier; molecular markers; risk group stratification; treatment.

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