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. 2016 Mar 18;11(3):e0151381.
doi: 10.1371/journal.pone.0151381. eCollection 2016.

Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Cecilia Forcato  1 , Luz Bavassi  1 , Gabriela De Pino  2   3 , Rodrigo Sebastián Fernández  1 , Mirta Fabiana Villarreal  2   4 , María Eugenia Pedreira  1
Affiliations

Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

Cecilia Forcato et al. PLoS One. .

Abstract

Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Experimental Design.
Fig 2
Fig 2. Experiment 1.
Mean percentage of correct responses at testing session ± SEM, for the different groups and types of reminders. *, p<0.05; **, p<0.01 and ***, p<0.001.
Fig 3
Fig 3. t-maps.
Comparison between reminder conditions for the trained group (p<0.05 FWE corrected p-value, cluster size).
Fig 4
Fig 4. ROI analysis.
β-values for the left hippocampal for the trained and untrained group.
See this image and copyright information in PMC

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