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. 2016 Jul;111(1):8-15.
doi: 10.1111/vox.12378. Epub 2016 Mar 18.

Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data

A Jordan  1   2 , D Chen  3   4 , Q-L Yi  5 , T Kanias  6   7 , M T Gladwin  6   7   8 , J P Acker  1   2
Affiliations

Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data

A Jordan et al. Vox Sang. 2016 Jul.

Abstract

Background and objectives: Quality control (QC) data collected by blood services are used to monitor production and to ensure compliance with regulatory standards. We demonstrate how analysis of quality control data can be used to highlight the sources of variability within red cell concentrates (RCCs).

Materials and methods: We merged Canadian Blood Services QC data with manufacturing and donor records for 28 227 RCC between June 2011 and October 2014. Units were categorized based on processing method, bag manufacturer, donor age and donor sex, then assessed based on product characteristics: haemolysis and haemoglobin levels, unit volume, leucocyte count and haematocrit.

Results: Buffy-coat method (top/bottom)-processed units exhibited lower haemolysis than units processed using the whole-blood filtration method (top/top). Units from female donors exhibited lower haemolysis than male donations. Processing method influenced unit volume and the ratio of additive solution to residual plasma.

Conclusions: Stored red blood cell characteristics are influenced by prestorage processing and donor factors. Understanding the relationship between processing, donors and RCC quality will help blood services to ensure the safety of transfused products.

Keywords: RBC processing; RBC storage; buffy coat; donor characteristics; product variability; quality control; whole-blood filtration.

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