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Comparative Study
. 2016 Jul;174(1):148-52.
doi: 10.1111/bjh.14040. Epub 2016 Mar 17.

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

Louise Nielsen  1   2 , Florence Canouï-Poitrine  3   4 , Jean-Philippe Jais  5   6 , Djamal Dahmane  1 , Pablo Bartolucci  7   8   9 , Bouteina Bentaarit  1 , Justine Gellen-Dautremer  7 , Philippe Remy  1   2 , Tomek Kofman  1   2 , Marie Matignon  1   2 , Caroline Suberbielle  10 , Christian Jacquelinet  11   12 , Orianne Wagner-Ballon  13   14 , Dil Sahali  1   2 , Philippe Lang  1   2 , Thibaud Damy  15   16 , Frédéric Galactéros  7   8   9 , Philippe Grimbert  1   2 , Anoosha Habibi  7   8   9 , Vincent Audard  1   2
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Comparative Study

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

Louise Nielsen et al. Br J Haematol. 2016 Jul.

Abstract

We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

Keywords: dialysis; kidney; sickle cell disease; survival; vaso-occlusive crises.

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