Comparative Study

. 2016 Jul;174(1):148-52.

doi: 10.1111/bjh.14040. Epub 2016 Mar 17.

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

Louise Nielsen^{1

2}, Florence Canouï-Poitrine^{3

4}, Jean-Philippe Jais^{5

6}, Djamal Dahmane¹, Pablo Bartolucci^{7

8

9}, Bouteina Bentaarit¹, Justine Gellen-Dautremer⁷, Philippe Remy^{1

2}, Tomek Kofman^{1

2}, Marie Matignon^{1

2}, Caroline Suberbielle¹⁰, Christian Jacquelinet^{11

12}, Orianne Wagner-Ballon^{13

14}, Dil Sahali^{1

2}, Philippe Lang^{1

2}, Thibaud Damy^{15

16}, Frédéric Galactéros^{7

8

9}, Philippe Grimbert^{1

2}, Anoosha Habibi^{7

8

9}, Vincent Audard^{1

2}

Affiliations

¹ AP-HP (Assistance Publique-Hôpitaux de Paris), Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France.
² Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunity-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.
³ AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Santé Publique, Créteil, France.
⁴ UPEC, DHU A-TVB (Aging-Thorax-Vessels-Blood), IMRB, EA 4393 CEpiA (Clinical Epidemiology And Ageing Unit), Créteil, France.
⁵ Université Paris Descartes, INSERM UMRS 1138 Equipe 22, Paris, France.
⁶ AP-HP, Hôpital Necker Enfants Malades, Biostatistics & Ile de France REIN Registry Epidemiologic Units, Paris, France.
⁷ AP-HP, Centre de Référence des Syndromes Drépanocytaires Majeurs, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
⁸ AP-HP, Service de Médecine Interne, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
⁹ UPEC, INSERM 955, Equipe 2 Emergente, Créteil, France.
¹⁰ Laboratoire Régional d'Histocompatibilité, Hôpital Saint-Louis, Paris, France.
¹¹ Pôle Rein-Simulation, Direction Générale Médicale et Scientifique, Agence de la Biomédecine, Saint Denis, France.
¹² Inserm U1018, Centre de Recherches en Épidémiologie et Santé des Populations, Villejuif, France.
¹³ APHP, Département d'Hématologie et d'Immunologie Biologiques, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
¹⁴ UPEC, INSERM U955, Equipe 9, DHU VIC, Créteil, France.
¹⁵ APHP, Département de Cardiologie and Réseau Amylose Mondor, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
¹⁶ UPEC, INSERM U955, Groupe de Recherche Clinique (GRC) Amyloid Research Insitute, DHU A-TVB, Créteil, France.

PMID: 26992059
DOI: 10.1111/bjh.14040

Comparative Study

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

Louise Nielsen et al. Br J Haematol. 2016 Jul.

. 2016 Jul;174(1):148-52.

doi: 10.1111/bjh.14040. Epub 2016 Mar 17.

Authors

Affiliations

¹ AP-HP (Assistance Publique-Hôpitaux de Paris), Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Créteil, France.
² Université Paris-Est-Créteil, (UPEC), DHU (Département Hospitalo-Universitaire) VIC (Virus-Immunity-Cancer), IMRB (Institut Mondor de Recherche Biomédicale), Equipe 21, INSERM U 955, Créteil, France.
³ AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service de Santé Publique, Créteil, France.
⁴ UPEC, DHU A-TVB (Aging-Thorax-Vessels-Blood), IMRB, EA 4393 CEpiA (Clinical Epidemiology And Ageing Unit), Créteil, France.
⁵ Université Paris Descartes, INSERM UMRS 1138 Equipe 22, Paris, France.
⁶ AP-HP, Hôpital Necker Enfants Malades, Biostatistics & Ile de France REIN Registry Epidemiologic Units, Paris, France.
⁷ AP-HP, Centre de Référence des Syndromes Drépanocytaires Majeurs, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
⁸ AP-HP, Service de Médecine Interne, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
⁹ UPEC, INSERM 955, Equipe 2 Emergente, Créteil, France.
¹⁰ Laboratoire Régional d'Histocompatibilité, Hôpital Saint-Louis, Paris, France.
¹¹ Pôle Rein-Simulation, Direction Générale Médicale et Scientifique, Agence de la Biomédecine, Saint Denis, France.
¹² Inserm U1018, Centre de Recherches en Épidémiologie et Santé des Populations, Villejuif, France.
¹³ APHP, Département d'Hématologie et d'Immunologie Biologiques, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
¹⁴ UPEC, INSERM U955, Equipe 9, DHU VIC, Créteil, France.
¹⁵ APHP, Département de Cardiologie and Réseau Amylose Mondor, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France.
¹⁶ UPEC, INSERM U955, Groupe de Recherche Clinique (GRC) Amyloid Research Insitute, DHU A-TVB, Créteil, France.

PMID: 26992059
DOI: 10.1111/bjh.14040

Abstract

We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

Keywords: dialysis; kidney; sickle cell disease; survival; vaso-occlusive crises.

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Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

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Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

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