Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Aug;14(4):e417-22.
doi: 10.1016/j.clgc.2016.02.001. Epub 2016 Feb 23.

Lumbosacral Plexus Involvement as the First Site of Metastatic Recurrence in a Patient With CTNNB1-Mutant Prostate Cancer

Mark C Markowski  1 , Sara E Wobker  2 , Roy E Strowd 3rd  3 , Emmanuel S Antonarakis  4
Affiliations
Case Reports

Lumbosacral Plexus Involvement as the First Site of Metastatic Recurrence in a Patient With CTNNB1-Mutant Prostate Cancer

Mark C Markowski et al. Clin Genitourin Cancer. 2016 Aug.
No abstract available

Keywords: Biochemical recurrence; Neurofibroma; Perineural invasion; Wnt; β-Catenin.

PubMed Disclaimer

Conflict of interest statement

Disclosure

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Magnetic Resonance Imaging (MRI) Scan of the Pelvis Before and 12 Months After Treatment With Androgen Deprivation Therapy. Magnetic Resonance Imaging of Pelvis With and Without Gadolinium Including T1-Weighted Gadolinium-Enhanced Coronal (A,C) and T2-Weighted Axial Views (B,D) Showing Marked Bilateral Enlargement With Perineural and Intraneural Enhancement of the S2-S3 Nerve Roots Before Treatment (Arrows, A), With Resulting Decrease in Size and Enhancement (Arrows, C), and Restricted Diffusion (Data Not Shown) After Androgen Deprivation Therapy. Smooth Expansion of the S2-S3 Neural Foramina Was Present Bilaterally (B) With Reduced T2-Weighted Hyperintensity After Hormonal Treatment (D)
Figure 2
Figure 2
Histopathologic Analysis of Metastatic Prostate Adenocarcinoma. (A) Hematoxylin and Eosin (H&E)-Stained Section of Metastatic Prostatic Ductal Adenocarcinoma Involving Fibrous Tissue (Original Magnification ×20). (B) NKX3.1-Positive Nuclei of the Neoplastic Cells (Original Magnification ×20). (C) P501S (Prostein) Immunohistochemistry Demonstrates Clumpy, Granular Cytoplasmic Staining (Original Magnification ×20). (D) Prostate-Specific Antigen (PSA) Protein Detected at Low Levels, a Common Finding in Higher Grade Prostate Cancer (Original Magnification ×20)
See this image and copyright information in PMC

References

    1. Paller CJ, Antonarakis ES, Eisenberger MA, Carducci MA. Management of patients with biochemical recurrence after local therapy for prostate cancer. Hematol Oncol Clin North Am 2013; 27:1205–19. - PMC - PubMed
    1. Bubendorf L, Schopfer A, Wagner U, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 2000; 31:578–83. - PubMed
    1. Tazi H, Manunta A, Rodriguez A, Patard JJ, Lobel B, Guille F. Spinal cord compression in metastatic prostate cancer. Eur Urol 2003; 44:527–32. - PubMed
    1. Babu MA, Spinner RJ, Dyck PJ, et al. Recurrent prostatic adenocarcinoma with perineural spread to the lumbosacral plexus and sciatic nerve: comparing high resolution MRI with torso and endorectal coils and F-18 FDG and C-11 choline PET/CT. Abdom Imaging 2013; 38:1155–60. - PubMed
    1. Capek S, Howe BM, Tracy JA, Garcia JJ, Amrami KK, Spinner RJ. Prostate cancer with perineural spread and dural extension causing bilateral lumbosacral plexopathy: case report. J Neurosurg 2015; 122:778–83. - PubMed

Publication types