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. 2016 Mar:39:41-4.
doi: 10.1016/j.placenta.2016.01.006. Epub 2016 Jan 12.

Maternal obesity alters the apelinergic system at the feto-maternal interface

Sandy Hanssens  1 , Aurore Marx-Deseure  1 , Simon Lecoutre  2 , Laura Butruille  3 , Audren Fournel  4 , Claude Knauf  4 , Capucine Besengez  3 , Christophe Breton  2 , Laurent Storme  5 , Philippe Deruelle  1 , Jean Lesage  6
Affiliations

Maternal obesity alters the apelinergic system at the feto-maternal interface

Sandy Hanssens et al. Placenta. 2016 Mar.

Abstract

Apelin and its receptor APJ have been implicated in pathologies including cardiovascular disease, diabetes and obesity. Little is known about the function of the apelinergic system during gestation. We evaluated in mice this system at the feto-maternal interface in insulin-resistant obese female (HF) mice. Maternal apelinemia was decreased at term and fetal apelinemia was sixfold higher than maternal level. Ex-vivo, the placenta releases apelin at E12.5 and E18.5. In HF pregnant mice at term, apelinemia as well as placental apelin and APJ mRNA levels were increased whereas placental release of apelin was drastically reduced compared to controls.

Keywords: APJ; Apelin; Fetus; Maternal obesity; Mice; Placenta.

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