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Review
. 2013 Jan-Apr;7(1):11-6.
doi: 10.5005/jp-journals-10008-1130. Epub 2013 Jan 15.

A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate

William C Stewart  1 , Jeffrey C Oehler  2 , Neil T Choplin  3 , Joseph I Markoff  4 , Marlene R Moster  5 , Parul Ichhpujani  6 , Lindsay A Nelson  7
Affiliations
Review

A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate

William C Stewart et al. J Curr Glaucoma Pract. 2013 Jan-Apr.

Abstract

Objective: To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.

Design: A prospective, multicenter, observational, non-interventional study.

Participants: One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice daily) or timolol maleate with potassium sorbate once daily as monotherapy or as a part of two-drug therapy.

Materials and methods: Study was performed at seven clinical sites in the United States. Patients were surveyed on comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate.

Results: A difference between timolol hemihydrate and timolol maleate with potassium sorbate for questions 1 (burning/stinging on instillation, p < 0.001) and 4 (tearing on instillation, p = 0.024) was noted. There were no differences between treatment groups for any other question (p > 0.05).

Conclusion: This survey suggests that timolol hemihydrate is associated with less stinging/burning and tearing than timolol maleate with potassium sorbate. How to cite this article: Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate. J Current Glau Prac 2013;7(1):11-16.

Keywords: Betimol; Comfort; Glaucoma; Istalol; Timolol hemihydrate; Timolol maleate with potassium sorbate..

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Conflict of interest statement

Source of support: Nil

Conflict of interest: None declared

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