Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jan-Apr;8(1):15-9.
doi: 10.5005/jp-journals-10008-1155. Epub 2014 Jan 16.

Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma

Sunil Ganekal  1 , Syril Dorairaj  2 , Vishal Jhanji  3 , Krishnaprasad Kudlu  4
Affiliations
Review

Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma

Sunil Ganekal et al. J Curr Glaucoma Pract. 2014 Jan-Apr.

Abstract

Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes.

Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment.

Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period.

Conclusion: Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucoma How to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19.

Keywords: Calcium channel blockers; Intraocular pressure; Steroid-induced glaucoma..

PubMed Disclaimer

Conflict of interest statement

Source of support: Nil

Conflict of interest: None

Figures

Fig. 1
Fig. 1
Intraocular pressure changes in treatment and control eyes during study period in 0.5% diltiazem treated rabbits (group A)
Fig. 2
Fig. 2
Intraocular pressure changes in treatment and control eyes during study period in 0.125% verapamil treated rabbits (group B)
Fig. 3
Fig. 3
Intraocular pressure changes in treatment and control eyes during study period in 0.5% timolol treated rabbits
Fig. 4
Fig. 4
Comparison of intraocular pressure changes in right (treatment) eyes in I-0.5% diltiazem, II-0.125% verapamil and III-0.5% timolol-treated rabbits during study period
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kumarasamy NA, Lam FS, Wang AL, Theoharides TC. Glaucoma: current and developing concepts of infammation, patho-genesis and treatment. Eur J Infamm. 2006 Oct;4(3):129–137.
    1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004 Nov;82(11):844–851. - PMC - PubMed
    1. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002 Jun;120(6):701–713. - PubMed
    1. Hof RP. Calcium antagonist and peripheral circulation: diffe rences and similarities between PY 108-068, nicardipine, vera pamil and diltiazem. Br J Pharmacol. 1983 Feb;78(2):375–394. - PMC - PubMed
    1. Ohtsuka M, Yokota M, Kodama I, Yamada K, Shibata S. New generation dihydropyridine calcium entry blockers: in search of greater selectivity for one tissue subtype. Gen Pharmacol. 1989;20(5):539–556. - PubMed