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Review
. 2014 Jan-Apr;8(1):15-9.
doi: 10.5005/jp-journals-10008-1155. Epub 2014 Jan 16.

Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma

Sunil Ganekal  1 , Syril Dorairaj  2 , Vishal Jhanji  3 , Krishnaprasad Kudlu  4
Affiliations
Review

Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma

Sunil Ganekal et al. J Curr Glaucoma Pract. 2014 Jan-Apr.

Abstract

Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes.

Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment.

Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period.

Conclusion: Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucoma How to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19.

Keywords: Calcium channel blockers; Intraocular pressure; Steroid-induced glaucoma..

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Conflict of interest statement

Source of support: Nil

Conflict of interest: None

Figures

Fig. 1
Fig. 1
Intraocular pressure changes in treatment and control eyes during study period in 0.5% diltiazem treated rabbits (group A)
Fig. 2
Fig. 2
Intraocular pressure changes in treatment and control eyes during study period in 0.125% verapamil treated rabbits (group B)
Fig. 3
Fig. 3
Intraocular pressure changes in treatment and control eyes during study period in 0.5% timolol treated rabbits
Fig. 4
Fig. 4
Comparison of intraocular pressure changes in right (treatment) eyes in I-0.5% diltiazem, II-0.125% verapamil and III-0.5% timolol-treated rabbits during study period
See this image and copyright information in PMC

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