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. 2016 Mar;11(3):2140-2144.
doi: 10.3892/ol.2016.4202. Epub 2016 Feb 8.

Epithelial membrane protein 1 expression in ovarian serous tumors

Guzin Gonullu Demirag  1 , Mehmet Kefeli  2 , Yasemin Kemal  1 , Idris Yucel  1
Affiliations

Epithelial membrane protein 1 expression in ovarian serous tumors

Guzin Gonullu Demirag et al. Oncol Lett. 2016 Mar.

Abstract

The present study aimed to analyze the clinical significance of epithelial membrane protein 1 (EMP1) expression in ovarian serous tumors. A total of 84 cases of ovarian serous tumor (50 patients with malignant ovarian serous tumors and 34 patients with borderline and benign serous tumors) were retrospectively analyzed. Differences in the expression levels of EMP1 between the malignant and non-malignant tumor groups were evaluated by immunohistochemical staining. In addition, the association between EMP1 expression and prognostic factors in malignant ovarian serous tumors was investigated. The expression levels of EMP1 were significantly reduced in all the 50 malignant ovarian serous tumors, compared with the 34 non-malignant ovarian serous tumors (P<0.000). Reduced expression of EMP1 was correlated with high grade (P=0.009) and stage (P<0.000) of malignant tumors. EMP1 expression was not observed to be correlated with any other investigated parameters, including surgery, type of operation and chemotherapy response (P>0.005). These results indicated that EMP1 may have a significant role as a negative regulator in ovarian serous tumors, and reduced EMP1 expression in serous tumors may be associated with increased disease severity.

Keywords: epithelial membrane protein 1; ovary; prognosis; serous tumors.

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Figures

Figure 1.
Figure 1.
Light microscopy images of epithelial membrane protein 1 (EMP1) expression in high-grade ovarian serous adenocarcinoma samples. (A and B) Representative samples of ovarian serous adenocarcinoma demonstrating no expression of EMP1. Representative images of (C) weak and (D) strong staining for EMP1 (3,3′-diaminobenzidine staining; magnification, ×200).
Figure 2.
Figure 2.
Light microscopy images of epithelial membrane protein 1 (EMP1) expression in borderline and benign ovarian serous tumor samples. Representative images of (A) weak and (B) strong staining for EMP1 in borderline serous tumor samples. (C and D) Strong staining for EMP1 in two representative benign serous tumor samples (3,3′-diaminobenzidine staining; magnification, ×200).
See this image and copyright information in PMC

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