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. 2016 Jan 1;6(16):12959-12963.
doi: 10.1039/C5RA25044G. Epub 2016 Jan 26.

Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin

Aline A Ishikawa  1 , Jesus V Salazar  2 , Magaly Salinas  3 , Cristiane M Gaitani  4 , Timothy Nurkiewicz  5 , George R Negrete  3 , Carlos D Garcia  6
Affiliations

Self-Assembled Nanospheres for Encapsulation and Aerosolization of Rifampicin

Aline A Ishikawa et al. RSC Adv. .

Abstract

Rifampicin (RIF) is a benchmark drug for treatment of tuberculosis, but poor bioavailability, prolonged treatment, and pill burden have been linked to therapeutic failure and the development of multidrug resistant strains. To overcome these limitations, this study investigated a method of rifampicin nanoencapsulation and aerosol delivery using a commercial, hand-held nebulizer modified with a nitrogen stream.

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Figures

Figure 1
Figure 1
Structure of the amphiphile ALA-11, used to develop the aerosolized NPs.
Figure 2
Figure 2
Relative abundance as a function of the RIF/NP diameter (in log scale) collected using a flow of N2 of 2 L/min ( formula image) or 5 L/min ( formula image). Inserts: Micrograph of NP analyzed by high resolution scanning electron microscope (STEM) FE Hitachi S-5500 (0.4 nm at 5kV) with a BF/DF Duo-STEM detector.
Figure 3
Figure 3
Images isolated of an empty nanoparticle (A), pure rifampicin (B) and rifampicin/nanoparticle (C)
Figure 4
Figure 4
Dependence of the amount of RIF encapsulated in the NP as a function of the amount of RIF used to prepare the NP/RIF composite. Line included to guide the eye.
Figure 5
Figure 5
Stability of NP evaluated thought absorbance of RIF measured day by day. Line included to guide the eye.
See this image and copyright information in PMC

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