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. 2016 Apr 6;138(13):4314-7.
doi: 10.1021/jacs.6b00976. Epub 2016 Mar 24.

Enantioselective Aminomethylamination of Conjugated Dienes with Aminals Enabled by Chiral Palladium Complex-Catalyzed C-N Bond Activation

Yang Liu  1   2 , Yinjun Xie  1 , Hongli Wang  1 , Hanmin Huang  1
Affiliations

Enantioselective Aminomethylamination of Conjugated Dienes with Aminals Enabled by Chiral Palladium Complex-Catalyzed C-N Bond Activation

Yang Liu et al. J Am Chem Soc. .

Abstract

A novel highly enantioselective aminomethylamination of conjugated dienes with aminals catalyzed by a chiral palladium complex ligated with BINOL-derived chiral diphosphinite has been successfully developed. This reaction proceeds via a Pd-catalyzed cascade C-N bond activation, aminomethylation, and asymmetric allylic amination reaction under mild reaction conditions, providing a unique and efficient strategy for the synthesis of enantiomerically pure allylic 1,3-diamines.

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