Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Emerson M Wickwire^{1

2}, Scott G Williams^{3

4}, Thomas Roth⁵, Vincent F Capaldi⁶, Michael Jaffe^{7

8

9}, Margaret Moline¹⁰, Gholam K Motamedi¹¹, Gregory W Morgan¹², Vincent Mysliwiec^{4

13}, Anne Germain¹⁴, Renee M Pazdan¹⁵, Reuven Ferziger¹⁶, Thomas J Balkin⁶, Margaret E MacDonald¹⁷, Thomas A Macek¹⁸, Michael R Yochelson^{19

20}, Steven M Scharf²¹, Christopher J Lettieri⁴

Affiliations

¹ Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. ewickwire@medicine.umaryland.edu.
² Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. ewickwire@medicine.umaryland.edu.
³ Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA.
⁴ Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
⁵ Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA.
⁶ Department of Behavioral Biology, Walter Reed Army Institute of Research, Center for Military Psychiatry and Neuroscience Research, Silver Spring, MD, USA.
⁷ Department of Neurology, University of Florida, Gainesville, FL, USA.
⁸ Concussion and Sports Program, University of Florida Trauma, Gainesville, FL, USA.
⁹ UF Health Sleep Disorders Center, Gainesville, FL, USA.
¹⁰ Eisai, Inc., Woodcliff Lake, NJ, USA.
¹¹ Department of Neurology, Georgetown University Hospital, Washington, DC, USA.
¹² Sleep Disorders Center, National Intrepid Center of Excellence, Bethesda, MD, USA.
¹³ Department of Sleep Medicine, San Antonio Military Medical Center, San Antonio, TX, USA.
¹⁴ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁵ U.S. Public Health Service, Fort Carson, CO, USA.
¹⁶ Merck and Co, Kenilworth, NJ, USA.
¹⁷ Defense and Veterans Brain Injury Center, (Contractor, General Dynamics Health Solutions), Evans Army Community Hospital, Fort Carson, CO, USA.
¹⁸ Department of Clinical Science, CNS, Takeda Development Center - Americas, Deerfield, IL, USA.
¹⁹ Medstar National Rehabilitation Network, Washington, DC, USA.
²⁰ Departments of Neurology and Rehabilitation Medicine, Georgetown University School of Medicine, Washington, DC, USA.
²¹ Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

PMID: 27002812
PMCID: PMC4824019
DOI: 10.1007/s13311-016-0429-3

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Emerson M Wickwire et al. Neurotherapeutics. 2016 Apr.

. 2016 Apr;13(2):403-17.

doi: 10.1007/s13311-016-0429-3.

Authors

Affiliations

¹ Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. ewickwire@medicine.umaryland.edu.
² Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. ewickwire@medicine.umaryland.edu.
³ Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA.
⁴ Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
⁵ Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA.
⁶ Department of Behavioral Biology, Walter Reed Army Institute of Research, Center for Military Psychiatry and Neuroscience Research, Silver Spring, MD, USA.
⁷ Department of Neurology, University of Florida, Gainesville, FL, USA.
⁸ Concussion and Sports Program, University of Florida Trauma, Gainesville, FL, USA.
⁹ UF Health Sleep Disorders Center, Gainesville, FL, USA.
¹⁰ Eisai, Inc., Woodcliff Lake, NJ, USA.
¹¹ Department of Neurology, Georgetown University Hospital, Washington, DC, USA.
¹² Sleep Disorders Center, National Intrepid Center of Excellence, Bethesda, MD, USA.
¹³ Department of Sleep Medicine, San Antonio Military Medical Center, San Antonio, TX, USA.
¹⁴ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁵ U.S. Public Health Service, Fort Carson, CO, USA.
¹⁶ Merck and Co, Kenilworth, NJ, USA.
¹⁷ Defense and Veterans Brain Injury Center, (Contractor, General Dynamics Health Solutions), Evans Army Community Hospital, Fort Carson, CO, USA.
¹⁸ Department of Clinical Science, CNS, Takeda Development Center - Americas, Deerfield, IL, USA.
¹⁹ Medstar National Rehabilitation Network, Washington, DC, USA.
²⁰ Departments of Neurology and Rehabilitation Medicine, Georgetown University School of Medicine, Washington, DC, USA.
²¹ Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

PMID: 27002812
PMCID: PMC4824019
DOI: 10.1007/s13311-016-0429-3

Abstract

Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

Keywords: Concussion; Insomnia; Sleep; Sleep apnea; Sleep disorders; Traumatic brain injury.

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Conflict of interest statement

The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of Defense or Veterans Affairs position, policy or decision unless so designated by other documentation.

References

1. Faul M, Xu L, Wald MM, Coronado V. Traumatic brain injury in the United States. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; 2010.
1. Leo P, McCrea M. Epidemiology. In: Laskowitz D, Grant G, editors. Translational research in traumatic brain injury. Boca Raton (FL): by Taylor & Francis Group, LLC; 2016. - PubMed
1. National Center for Injury Prevention and Control. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to prevent a serious public health problem. 2003.
1. Corrigan JD, Selassie AW, Orman JA. The epidemiology of traumatic brain injury. J Head Trauma Rehabil. 2010;25:72–80. doi: 10.1097/HTR.0b013e3181ccc8b4. - DOI - PubMed
1. Gerberding J. for the National Center for Injury Prevention and Control. Report to congress on mild traumatic brain injury in the United States—steps to prevent a serious public health problem. 2003.

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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Affiliations

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials