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Comment
. 2016 Mar 21;36(6):592-4.
doi: 10.1016/j.devcel.2016.03.007.

Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity

Nathan H Roy  1 , Janis K Burkhardt  2
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Embracing the Enemy: Cell-to-Cell Force Transmission Enhances Cytotoxicity

Nathan H Roy et al. Dev Cell. .
Free article

Abstract

Cells respond to the mechanical properties of their environment, but how biomechanics contributes to intercellular signaling remains unclear. Reporting in Cell, Basu et al. (2016) showed that forces exerted by cytotoxic T lymphocytes enhance the function of the pore-forming protein perforin, thereby leading to more effective target cell killing.

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