Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016;89(1):11-8.
doi: 10.15386/cjmed-505. Epub 2016 Jan 15.

The role of hormones in the pathogenesis of psoriasis vulgaris

Iulia Ioana Roman  1 , Anne-Marie Constantin  2 , Mihaela Elena Marina  2 , Remus Ioan Orasan  1
Affiliations
Review

The role of hormones in the pathogenesis of psoriasis vulgaris

Iulia Ioana Roman et al. Clujul Med. 2016.

Abstract

Psoriasis vulgaris is a chronic, common skin disease, which affects the patient's quality of life to the highest degree. Several exogenous factors and endogenous hormonal changes may act as triggers for psoriasis. The skin possesses a true endocrine system, which is very important in multiple systemic diseases. A number of conditions are associated with psoriasis, and its severity can also be influenced by hormones. Even though the sex hormones and prolactin have a major role in psoriasis pathogenicity, there are a lot of other hormones which can influence the psoriasis clinical manifestations: glucocorticoids, epinephrine, thyroid hormones, and insulin.

Keywords: glucocorticoids; prolactin; psoriasis vulgaris; sex hormones.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Positive and negative effects of estrogens, differently mediated by ER-α and ER-β [–71].
Figure 2
Figure 2
Loop of keratinocytes activation: stressing factors activate the immune cells, which produce cytokines that cause inflammation, which in turn activates more cytokine-producing cells, altering the keratinocytes proliferations and genetic expression. VEGF production is a major pathogenic factor in psoriasis.
See this image and copyright information in PMC

References

    1. Gudjonsson JE, Elder JT. Psoriasis: epidemiology. Clin Dermatol. 2007;25(6):535–546. - PubMed
    1. Liu Y, Krueger JG, Bowcock AM. Psoriasis: genetic associations and immune system changes. Genes Immun. 2007;8(1):1–12. - PubMed
    1. Batycka-Baran A, Maj J, Wolf R, Szepietowski JC. The new insight into the role of antimicrobial proteins-alarmins in the immunopathogenesis of psoriasis. J Immunol Res. 2014 doi: 10.1155/2014/628289. - DOI - PMC - PubMed
    1. Schafer T. Epidemiology of psoriasis. Review and the German perspective. Dermatology. 2006;212(4):327–337. - PubMed
    1. Naldi L. Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy. 2004;3(2):121–128. - PubMed

LinkOut - more resources