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Review
. 2016 Mar 8;5(1):10.
doi: 10.3390/cells5010010.

Hypoxia Induced NF-κB

Laura D'Ignazio  1 , Sonia Rocha  2
Affiliations
Review

Hypoxia Induced NF-κB

Laura D'Ignazio et al. Cells. .

Abstract

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.

Keywords: FIH; HIF-1; Hypoxia; IKK; NF-κB; PHDs; TAK; ubiquitin.

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Figures

Figure 1
Figure 1
Mechanism of hypoxia induced Nuclear Factor-κB (NF-κB). Schematic diagram depicting the overview of the mechanism behind hypoxia induced NF-κB. Hypoxia induced NF-κB has been shown to require Calcium, Transforming Growth Factor-B activating kinase (TAK1) and Inhibitor of κB kinase complex (IKK). In addition, contributions from dioxygenases such as prolyl-hydroxylases (PHDs) and factor inhibiting HIF (FIH) have been reported. Unanswered questions into the mechanisms of hypoxia induced NF-κB are highlighted as questions marks. SENPs-Sentrin/SUMO specific proteases; S2-Sumo-2.
See this image and copyright information in PMC

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