Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Sangeeta Dhami¹, Ulugbek Nurmatov², Graham Roberts³, Oliver Pfaar⁴, Antonella Muraro⁵, Ignacio J Ansotegui⁶, Moises Calderon⁷, Cemal Cingi⁸, Pascal Demoly⁹, Stephen Durham⁷, Ronald Gerth van Wijk¹⁰, Susanne Halken¹¹, Eckard Hamelmann¹², Peter Hellings¹³, Lars Jacobsen¹⁴, Edward Knol¹⁵, Desiree Larenas-Linnemann¹⁶, Sandra Lin¹⁷, Vivian Maggina¹⁸, Hanneke Oude-Elberink¹⁹, Giovanni Pajno²⁰, Ruby Panwankar²¹, Elideanna Pastorello²², Constantinos Pitsios²³, Giuseppina Rotiroti²⁴, Frans Timmermans²⁵, Olympia Tsilochristou²⁶, Eva-Maria Varga²⁷, Jamie Wilkinson²⁸, Andrew Williams²⁹, Margitta Worm³⁰, Luo Zhang³¹, Aziz Sheikh³²

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Systematic Review at Decision Resources Group Abacus International, Bicester, UK.
³ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK ; Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery University Hospital, Mannheim and Center for Rhinology and Allergology, Wiesbaden, Germany.
⁵ Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
⁶ Hospital Quiron Bizkair, Bilbao, Spain.
⁷ National Heart and Lung Institute, Imperial College, London, UK.
⁸ Department of ENT, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
⁹ University and Hospital of Montpellier, Inserm Paris Sorbonnes, Montpellier, France.
¹⁰ Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
¹¹ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
¹² Children's Center Bethel, EvKB, Bieledelf and Allergy Center Buhr-University, Bochum, Germany.
¹³ Laboratory of Experimental Immunology, University Hospitals Leuven, Louvain, Belgium.
¹⁴ ALC, Allergy Learning and Consulting, Copenhagen, Denmark.
¹⁵ University Medical Center, Utrecht, The Netherlands.
¹⁶ Hospital Medica Sur, Mexico City, Mexico.
¹⁷ Department of Otolaryngology-Head and Neck Surgery, John Hopkins, Baltimore, USA.
¹⁸ Allergy and Clinical Immunology Unit, 2nd Department of Pediatrics, University of Athens, P and A Kiriakou Children's Hospital, Athens, Greece.
¹⁹ Department of Allergology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁰ Department of Pediatrics, University of Messina, Messina, Italy.
²¹ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
²² University of Milano, Milan, Italy.
²³ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁴ The Royal National Throat, Nose and Ear Hospital, University College London, London, UK.
²⁵ Netherlands Anafylaxis Network, Dordrecht, The Netherlands.
²⁶ Charite University Hospital, Berlin, Germany.
²⁷ Dept. of Paediatrics, Respiratory and Allergic Disease Division, Medical University Graz, Graz, Austria.
²⁸ Pharmaceutical Group of the European Union, Brussels, Belgium.
²⁹ Guy's and St Thomas' NHS Foundation Trust, London, UK.
³⁰ Chartie-Universitatsmedizin, Berlin, Germany.
³¹ Beijing Institute of Otolarygology, Beijing, China.
³² Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK.

PMID: 27006751
PMCID: PMC4802892
DOI: 10.1186/s13601-016-0099-6

Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Sangeeta Dhami et al. Clin Transl Allergy. 2016.

. 2016 Mar 22:6:12.

doi: 10.1186/s13601-016-0099-6. eCollection 2016.

Authors

Affiliations

¹ Evidence-Based Health Care Ltd, Edinburgh, UK.
² Systematic Review at Decision Resources Group Abacus International, Bicester, UK.
³ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport Isle of Wight, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK ; Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery University Hospital, Mannheim and Center for Rhinology and Allergology, Wiesbaden, Germany.
⁵ Food Allergy Referral Centre Veneto Region, Department of Women and Child Health, Padua General University Hospital, Padua, Italy.
⁶ Hospital Quiron Bizkair, Bilbao, Spain.
⁷ National Heart and Lung Institute, Imperial College, London, UK.
⁸ Department of ENT, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey.
⁹ University and Hospital of Montpellier, Inserm Paris Sorbonnes, Montpellier, France.
¹⁰ Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
¹¹ Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
¹² Children's Center Bethel, EvKB, Bieledelf and Allergy Center Buhr-University, Bochum, Germany.
¹³ Laboratory of Experimental Immunology, University Hospitals Leuven, Louvain, Belgium.
¹⁴ ALC, Allergy Learning and Consulting, Copenhagen, Denmark.
¹⁵ University Medical Center, Utrecht, The Netherlands.
¹⁶ Hospital Medica Sur, Mexico City, Mexico.
¹⁷ Department of Otolaryngology-Head and Neck Surgery, John Hopkins, Baltimore, USA.
¹⁸ Allergy and Clinical Immunology Unit, 2nd Department of Pediatrics, University of Athens, P and A Kiriakou Children's Hospital, Athens, Greece.
¹⁹ Department of Allergology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁰ Department of Pediatrics, University of Messina, Messina, Italy.
²¹ Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
²² University of Milano, Milan, Italy.
²³ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁴ The Royal National Throat, Nose and Ear Hospital, University College London, London, UK.
²⁵ Netherlands Anafylaxis Network, Dordrecht, The Netherlands.
²⁶ Charite University Hospital, Berlin, Germany.
²⁷ Dept. of Paediatrics, Respiratory and Allergic Disease Division, Medical University Graz, Graz, Austria.
²⁸ Pharmaceutical Group of the European Union, Brussels, Belgium.
²⁹ Guy's and St Thomas' NHS Foundation Trust, London, UK.
³⁰ Chartie-Universitatsmedizin, Berlin, Germany.
³¹ Beijing Institute of Otolarygology, Beijing, China.
³² Allergy and Respiratory Research Group, The University of Edinburgh, Edinburgh, UK.

PMID: 27006751
PMCID: PMC4802892
DOI: 10.1186/s13601-016-0099-6

Erratum in

Erratum to: Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review.
Dhami S, Nurmatov U, Roberts G, Pfaar O, Muraro A, Ansotegui IJ, Calderon M, Cingi C, Demoly P, Durham S, van Wijk RG, Halken S, Hamelmann E, Hellings P, Jacobsen L, Knol E, Linnemann DL, Lin S, Maggina V, Oude-Elberink H, Pajno G, Panwankar R, Pastorello E, Pitsios C, Rotiroti G, Timmermans F, Tsilochristou O, Varga EM, Wilkinson J, Williams A, Worm M, Zhang L, Sheikh A. Dhami S, et al. Clin Transl Allergy. 2017 Sep 15;7:29. doi: 10.1186/s13601-017-0168-5. eCollection 2017. Clin Transl Allergy. 2017. PMID: 28932383 Free PMC article.

Abstract

Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for the Management of Allergic Rhinoconjunctivitis. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in the management of allergic rhinoconjunctivitis.

Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised.

Conclusion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.

Keywords: Allergen immunotherapy; Allergic rhinoconjunctivitis; Allergy; Rhinitis.

PubMed Disclaimer

Figures

**Fig. 1**
Conceptualization of systematic review of allergen immunotherapy for allergic rhinoconjunctivitis

See this image and copyright information in PMC

References

1. Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A, ISAAC Phase Three Study Group The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol. 2013;41:73–85. doi: 10.1016/j.aller.2012.03.001. - DOI - PubMed
1. Patil VK, Kurukulaaratchy RJ, Venter C, Grundy J, Roberts G, Dean T, et al. Changing prevalence of wheeze, rhinitis and allergic sensitisation in late childhood: findings from 2 Isle of Wight birth cohorts 12 years apart. Clin Exp Allergy. 2015;45:1430–1438. doi: 10.1111/cea.12534. - DOI - PubMed
1. Bousquet PJ, Demoly P, Devillier P, Mesbah K, Bousquet J. Impact of allergic rhinitis symptoms on quality of life in primary care. Int Arch Allergy Immunol. 2013;160:393–400. doi: 10.1159/000342991. - DOI - PubMed
1. Brożek Jan L, Bousquet Jean, Baena-Cagnani Carlos E, Bonini Sergio, Canonica GW, Casale TB, van Wijk RG, Ohta K. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision. J Allergy Clin Immunol. 2010;126(3):p466–p476. doi: 10.1016/j.jaci.2010.06.047. - DOI - PubMed
1. Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108(1 Suppl):S2–S8. doi: 10.1067/mai.2001.115569. - DOI - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Affiliations

Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Authors

Affiliations

Erratum in

Abstract

Figures

References

LinkOut - more resources

Full Text Sources

Other Literature Sources