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Review
. 2016 Jun 7;7(23):35478-89.
doi: 10.18632/oncotarget.8155.

Hallmarks of glycosylation in cancer

Jennifer Munkley  1 , David J Elliott  1
Affiliations
Review

Hallmarks of glycosylation in cancer

Jennifer Munkley et al. Oncotarget. .

Abstract

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour development and progression. Glycans have roles in cancer cell signalling, tumour cell dissociation and invasion, cell-matrix interactions, angiogenesis, metastasis and immune modulation. Aberrant glycosylation is often cited as a 'hallmark of cancer' but is notably absent from both the original hallmarks of cancer and from the next generation of emerging hallmarks. This review discusses how glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities. Rather than aberrant glycosylation being itself a hallmark of cancer, another perspective is that glycans play a role in every recognised cancer hallmark.

Keywords: aberrant; cancer; glycans; glycosylation; hallmarks.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Glycosylation is an enabling characteristic that is causally associated with the acquisition of all the cancer hallmark capabilities
See this image and copyright information in PMC

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