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Review
. 2016 May;18(3):605-11.
doi: 10.1208/s12248-016-9903-4. Epub 2016 Mar 23.

Recent Advances in Application of Pharmacogenomics for Biotherapeutics

Pramod B Mahajan  1
Affiliations
Review

Recent Advances in Application of Pharmacogenomics for Biotherapeutics

Pramod B Mahajan. AAPS J. 2016 May.

Abstract

Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations. Both of these issues, also commonly experienced with small molecule drugs, have been addressed effectively in a number of cases by the successful application of pharmacogenomic tools and approaches. In this introductory article of the special issue, we review the current state of application of pharmacogenomics to BTs and offer suggestions for further expansion of the field.

Keywords: biologicals; biotherapeutics; genetic variability; pharmacogenomics.

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Figures

Fig. 1
Fig. 1
Biotherapeutics licenses during 2001–2015*. *Data adapted from ref. (6); Numbers for 2015 up to April 30
See this image and copyright information in PMC

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