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. 2016 Jul 3;7(5):610-1.
doi: 10.1080/21505594.2016.1162371. Epub 2016 Mar 23.

Anti-apoptosis in porcine respiratory and reproductive syndrome virus

Sujit Pujhari  1   2 , Jason L Rasgon  1 , Alexander N Zakhartchouk  2
Affiliations

Anti-apoptosis in porcine respiratory and reproductive syndrome virus

Sujit Pujhari et al. Virulence. .
No abstract available

Keywords: anti-apoptosis; autophagy; caspase; cell survival; virus.

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Figures

Figure 1.
Figure 1.
Survival and apoptotic signaling kinetics in PRRSV infection. Pro-survival signaling cascade initiates within the first couple of hours of PRRSV post infection. Activation of IP3K/Akt follows mTOR and autophagy signaling. Literature demonstrates the possible role of GP2a and GP5 in pro-survival signaling. Apoptosis process starts somewhere between 36 h to 48 h post infection activating both mitochondrial dependent and mitochondrial independent pathways. NSP4 and E proteins trigger the apoptotic event. How NSP4 triggers the signaling cascade needs to be investigated, however E protein directly interacts with mitochondrial proteins as pictured above that alters the cellular ATP status and triggers apoptosis.
See this image and copyright information in PMC

References

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    1. Pujhari S, Zakhartchouk AN. Porcine Reproductive and Respiratory Syndrome Virus Envelope (E) protein interacts with mitochondrial proteins and induces apoptosis. Archives of virology (In press) - PubMed
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