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Comment
. 2016 Mar 23;8(331):331fs8.
doi: 10.1126/scitranslmed.aaf4953.

Metabolic control of arthritis: Switch pathways to treat

George C Tsokos  1
Affiliations
Comment

Metabolic control of arthritis: Switch pathways to treat

George C Tsokos. Sci Transl Med. .

Abstract

A shunting of glucose metabolism to the pentose phosphate pathway in rheumatoid arthritis T cells causes exhaustion of oxidants, enhanced cell proliferation, and differentiation toward the T helper 1 (TH1) and TH17 programs (Yanget al, this issue).

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