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Review
. 2016 May 12;90(11):5216-5218.
doi: 10.1128/JVI.00904-15. Print 2016 Jun 1.

Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions

Sarah S Wilson  1 , Mayim E Wiens  1 , Mayumi K Holly  1 , Jason G Smith  2
Affiliations
Review

Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions

Sarah S Wilson et al. J Virol. .

Abstract

Defensins are innate immune effector peptides expressed at mucosal surfaces throughout the human body and are potently antiviral in vitro The role of defensins in viral pathogenesis in vivo is poorly understood; however, recent studies have revealed that defensin-virus interactions in vivo are complicated and distinct from their proposed antiviral mechanisms in vitro These findings highlight the need for additional research that connects defensin neutralization of viruses in cell culture to in vivo antiviral mechanisms.

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Figures

FIG 1
FIG 1
Newly revealed roles for human defensins in viral infection and transmission. HPV16, human papillomavirus 16; HD5, human defensin 5; HIV-1, human immunodeficiency virus type 1; HNP1–3, human neutrophil peptides 1 through 3; CVL, cervical vaginal lavage fluid; HBD2, human β-defensin 2; MAdV-1, mouse adenovirus 1.
See this image and copyright information in PMC

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