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Multicenter Study
. 2016 Jun:27:102-6.
doi: 10.1016/j.parkreldis.2016.03.006. Epub 2016 Mar 12.

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

L M Chahine  1 , S X Xie  2 , T Simuni  3 , B Tran  2 , R Postuma  4 , A Amara  5 , W H Oertel  6 , A Iranzo  7 , C Scordia  2 , M Fullard  2 , C Linder  2 , R Purri  2 , A Darin  2 , L Rennert  2 , A Videnovic  8 , P Del Riva  9 , D Weintraub  2
Affiliations
Multicenter Study

Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder

L M Chahine et al. Parkinsonism Relat Disord. 2016 Jun.

Abstract

Introduction: Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains.

Methods: Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ≥6) and rate of change in cognitive variables. Age, sex, years of education, and baseline motor and cognitive scores were included as covariates.

Results: The baseline sample consisted of 423 individuals with PD, mean age 61.7 years and 65.5% male. Data was available on 389, 366, and 196 participants at 1-year, 2-year, and 3-year follow-up respectively. Possible RBD occurred in 108 (25.5%) at baseline. In multivariate analyses, baseline RBD was associated with greater annual rate of decline in MoCA score (β = -0.34, 95%CI -0.54, -0.13, p < 0.001), Symbol Digit Modalities Test (β = -0.69, 95%CI -1.3, -0.09, p = 0.024), and Hopkins Verbal Learning Test-Revised, delayed free recall (β = -0.21, 95%CI -0.41, -0.013, p = 0.037).

Conclusions: Possible RBD is common in early PD and predicts future cognitive decline, particularly in attention and memory domains.

Keywords: Cognition; Dementia; REM sleep behavior disorder.

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Conflict of interest statement

None of the authors have potential conflicts of interest that relate to the research covered in the article.

References

    1. Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson’s disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23:837–844. - PubMed
    1. de Lau LM, Schipper CM, Hofman A, Koudstaal PJ, Breteler MM. Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study. Arch Neurol. 2005;62:1265–1269. - PubMed
    1. Sixel-Doring F, Trautmann E, Mollenhauer B, Trenkwalder C. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology. 2011;77:1048–1054. - PubMed
    1. Postuma RB, Bertrand JA, Montplaisir J, Desjardins C, Vendette M, Rios Romenets S, Panisset M, Gagnon JF. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: a prospective study. Mov Disord. 2012;27:720–726. - PubMed
    1. Sinforiani E, Pacchetti C, Zangaglia R, Pasotti C, Manni R, Nappi G. REM behavior disorder, hallucinations and cognitive impairment in Parkinson’s disease: a two-year follow up. Mov Disord. 2008;23:1441–1445. - PubMed

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