Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 24;12(3):e1005453.
doi: 10.1371/journal.ppat.1005453. eCollection 2016 Mar.

Virus-Host Interactions and the ARTD/PARP Family of Enzymes

Chad V Kuny  1 , Christopher S Sullivan  1
Affiliations

Virus-Host Interactions and the ARTD/PARP Family of Enzymes

Chad V Kuny et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. ARTDs/PARPs regulate cellular processes that viruses manipulate.
ARTDs are involved in the regulation of multiple cellular stress responses. Virus infection is inherently stressful for the cell and often induces cellular stress responses in the course of replication. Stress-related pathways that are known to overlap between virus infection and ARTD activity are highlighted above. We have emphasized ARTD15’s role in PERK activation [10] and ARTD13’s ability to regulate RNA transcripts through direct (facilitating degradation of RNA [11,12]) and indirect (contributing to RISC inactivation [9]) mechanisms, while contributing to interferon production in response to molecular signatures of viral RNA [9,13]. We also indicate that multiple members of the ARTD family are interferon-stimulated genes (ISGs) [14,15], localize to stress granules [8], and contribute to DNA repair and overall metabolic changes in the cell [2,6,7].
See this image and copyright information in PMC

References

    1. Vyas S, Chang P. New PARP targets for cancer therapy. Nat Rev Cancer. 2014;14: 502–509. 10.1038/nrc3748 - DOI - PMC - PubMed
    1. Gibson BA, Kraus WL. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol. 2012;13: 411–424. 10.1038/nrm3376 - DOI - PubMed
    1. Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F. Toward a unified nomenclature for mammalian ADP-ribosyltransferases. Trends Biochem Sci. 2010;35: 208–219. 10.1016/j.tibs.2009.12.003 - DOI - PubMed
    1. Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, et al. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol. 2013;20: 508–514. 10.1038/nsmb.2523 - DOI - PMC - PubMed
    1. Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, et al. Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun. 2014;5: 4426 10.1038/ncomms5426 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources