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. 2016 Aug;249(4):493-501.
doi: 10.1007/s00232-016-9890-5. Epub 2016 Mar 24.

Nanovectorization of DNA Through Cells Using Protamine Complexation

Khaoula Boukari  1 , Cécile Caoduro  1 , Raoudha Kacem  1 , Nadia Skandrani  1 , Christophe Borg  2 , Hatem Boulahdour  1 , Tijani Gharbi  1 , Régis Delage-Mourroux  3 , Eric Hervouet  3 , Marc Pudlo  4 , Fabien Picaud  5
Affiliations

Nanovectorization of DNA Through Cells Using Protamine Complexation

Khaoula Boukari et al. J Membr Biol. 2016 Aug.

Abstract

Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.

Keywords: Nanovectorization; Protamine; Simulation.

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References

    1. Phys Chem Chem Phys. 2014 Sep 7;16(33):17883-92 - PubMed
    1. J Biol Chem. 2003 Dec 12;278(50):50212-6 - PubMed
    1. Bioessays. 1999 May;21(5):440-8 - PubMed
    1. Gene Ther. 1997 Sep;4(9):961-8 - PubMed
    1. J Nanoneurosci. 2009 Jun 1;1(1):10-16 - PubMed

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