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. 2016 Mar 11;113(10):159-66.
doi: 10.3238/arztebl.2016.0159.

Hospital Incidence and Mortality Rates of Sepsis

Carolin Fleischmann  1 , Daniel O Thomas-Rueddel, Michael Hartmann, Christiane S Hartog, Tobias Welte, Steffen Heublein, Ulf Dennler, Konrad Reinhart
Affiliations

Hospital Incidence and Mortality Rates of Sepsis

Carolin Fleischmann et al. Dtsch Arztebl Int. .

Abstract

Background: Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world. To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking.

Methods: Nationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence and mortality of sepsis. Cases were identified on the basis of the clinical and pathogen-based ICD-10 codes for sepsis. The statistical evaluation was standardized for age and sex and carried out separately for each age group.

Results: The number of cases of sepsis rose by an average of 5.7% per year, from 200 535 in 2007 to 279 530 in 2013, corresponding to an increase in the adjusted in-hospital incidence from 256 to 335 cases per 100 000 persons per year. The percentage of patients with severe sepsis rose from 27% to 41%. The in-hospital mortality of sepsis fell over the same period by 2.7%, to 24.3%. In 2013, 67 849 persons died of sepsis in German hospitals (or died of another disease, but also had sepsis). The incidence was highest in the youngest and oldest age groups, and the in-hospital mortality rose nearly linearly with age from age 40 onward.

Conclusion: Sepsis and death from sepsis are markedly more common in Germany than previously assumed, and they are on the rise. Sepsis statistics should become a standard component of federal statistical reports on public health, as well as of hospital statistics. Preventive measures and evidencebased treatment should be implemented across the nation.

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Figures

Figure 1
Figure 1
Incidence rate per 100 000 population, standardized to the German population structure in 2010, and in-hospital mortality of sepsis and severe sepsis (including septic shock) in Germany, 2007–2013
Figure 2
Figure 2
In-hospital incidence of sepsis per 100 000 persons per year, by age group and sex, in the period 2007–2013 (clinical and pathogen-based sepsis codes)
Figure 3
Figure 3
In-hospital mortality of patients with sepsis, by age group and sex, in the period 2007–2013 (clinical and pathogen-based sepsis codes)
See this image and copyright information in PMC

References

    1. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369 - PubMed
    1. Engel C, Brunkhorst FM, Bone HG, et al. Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med. 2007;33:606–618. - PubMed
    1. Hall MJ, Williams SN, DeFrances CJ, Golosinskiy A. Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. NCHS Data Brief. 2011:1–8. - PubMed
    1. Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42:625–631. - PMC - PubMed
    1. Lagu T, Rothberg MB, Shieh MS, Pekow PS, Steingrub JS, Lindenauer PK. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med. 2012;40:754–761. - PubMed

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