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Review
. 2016 Mar 22;17(3):428.
doi: 10.3390/ijms17030428.

Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

Lei Dang  1 , Jin Liu  2 , Fangfei Li  3 , Luyao Wang  4 , Defang Li  5 , Baosheng Guo  6 , Xiaojuan He  7 , Feng Jiang  8 , Chao Liang  9 , Biao Liu  10 , Shaikh Atik Badshah  11 , Bing He  12 , Jun Lu  13 , Cheng Lu  14 , Aiping Lu  15 , Ge Zhang  16
Affiliations
Review

Targeted Delivery Systems for Molecular Therapy in Skeletal Disorders

Lei Dang et al. Int J Mol Sci. .

Abstract

Abnormalities in the integral components of bone, including bone matrix, bone mineral and bone cells, give rise to complex disturbances of skeletal development, growth and homeostasis. Non-specific drug delivery using high-dose systemic administration may decrease therapeutic efficacy of drugs and increase the risk of toxic effects in non-skeletal tissues, which remain clinical challenges in the treatment of skeletal disorders. Thus, targeted delivery systems are urgently needed to achieve higher drug delivery efficiency, improve therapeutic efficacy in the targeted cells/tissues, and minimize toxicities in non-targeted cells/tissues. In this review, we summarize recent progress in the application of different targeting moieties and nanoparticles for targeted drug delivery in skeletal disorders, and also discuss the advantages, challenges and perspectives in their clinical translation.

Keywords: nanoparticles; skeletal disorders; targeted delivery systems; targeting moieties.

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Figures

Figure 1
Figure 1
The schematic graph of targeted delivery systems carrying drugs extravasated from bone sinusoid or blood vessels to different target cells in bone. The targets for drug delivery depend on the targeting moieties in the targeted delivery systems.
See this image and copyright information in PMC

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