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Clinical Trial
. 2016;85(5):301-8.
doi: 10.1159/000440955. Epub 2016 Mar 25.

First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test

And Demir  1 , Raimo Voutilainen, Ulf-Håkan Stenman, Leo Dunkel, Kerstin Albertsson-Wikland, Ensio Norjavaara
Affiliations
Clinical Trial

First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test

And Demir et al. Horm Res Paediatr. 2016.

Abstract

Aims: We studied whether first morning voided (FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the GnRH test in the assessment of the hypothalamic-pituitary-gonadal function in children.

Methods: In a single-center study, we compared FMV urinary gonadotropin concentrations with basal and GnRH-stimulated serum gonadotropin levels in 274 children and adolescents (78 girls, 196 boys) aged 5-17 years referred for growth and pubertal disorders. The concordance between FMV urinary gonadotropin concentrations and GnRH test results was assessed.

Results: FMV urinary LH (U-LH), urinary FSH (U-FSH) and their ratios correlated well with the corresponding basal and GnRH-stimulated serum parameters (r ≥ 0.66, p < 0.001). Receiver operating characteristic curve analyses using urinary and serum LH and FSH concentrations showed that FMV U-LH and U-LH/U-FSH performed equally well as the GnRH test in the differentiation of early puberty (Tanner stage 2) from prepuberty (Tanner stage 1) (area under the curve 0.768-0.890 vs. 0.712-0.858). FMV U-LH and U-LH/U-FSH performed equally well as basal serum LH in predicting a pubertal GnRH test result (area under the curve 0.90-0.93).

Conclusion: FMV U-LH determination can be used for the evaluation of pubertal development and its disorders, reducing the need for invasive GnRH stimulation tests.

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