Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016:23:15.
doi: 10.1051/parasite/2016015. Epub 2016 Mar 24.

Do advanced glycation end-products play a role in malaria susceptibility?

Karim Traoré  1 , Charles Arama  2 , Maurice Médebielle  3 , Ogobara Doumbo  2 , Stéphane Picot  4
Affiliations
Review

Do advanced glycation end-products play a role in malaria susceptibility?

Karim Traoré et al. Parasite. 2016.

Abstract
in English, French

There are growing data supporting the differences in susceptibility to malaria described between sympatric populations with different lifestyles. Evidence has also been growing for some time that nutritional status and the host's metabolism are part of the complex mechanisms underlying these differences. The role of dietary advanced glycation end-products (AGEs) in the modulation of immune responses (innate and adaptive responses) and chronic oxidative stress has been established. But less is known about AGE implication in naturally acquired immunity and susceptibility to malaria. Since inflammatory immune responses and oxidative events have been demonstrated as the hallmark of malaria infection, it seems crucial to investigate the role of AGE in susceptibility or resistance to malaria. This review provides new insight into the relationship between nutrition, metabolic disorders, and infections, and how this may influence the mechanisms of susceptibility or resistance to malaria in endemic areas.

De plus en plus de données étayent les différences de susceptibilité au paludisme décrites entre les populations sympatriques avec des modes de vie différents. Il existe également de plus en plus de preuves depuis un certain temps que l’état nutritionnel et les métabolismes de l’hôte font partie des mécanismes complexes qui sous-tendent ces différences. Le rôle des produits terminaux de glycation avancée d’origine alimentaire (AGE) dans la modulation des réponses immunitaires (réponses innée et adaptative) et le stress oxydatif chronique a été établi. Mais on connaît peu sur l’implication des AGE dans l’immunité naturellement acquise et la sensibilité au paludisme. Puisqu’il a été démontré que les réponses immunitaires de types inflammatoires et les événements oxydatifs sont caractéristiques de l’infection au paludisme, il semble primordial d’étudier le rôle des AGE dans la sensibilité de la résistance au paludisme. Cette synthèse fournit un nouvel aperçu sur la relation entre la nutrition, les maladies métaboliques et les infections, et comment cela peut influencer les mécanismes de susceptibilité ou de résistance au paludisme en zone d’endémie.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Major products resulting from the reaction of amino acids (from protein) and reducing sugars during the Maillard reaction.
Figure 2.
Figure 2.
Role of diet AGE in perpetuating oxidant stress and pro inflammatory cytokines production with deleterious effect on immunity. Abbreviation: AGE: Advanced glycation endproducts; Cdc42-Rac: cell division control protein 42 homolog-Rac; ERK1/2: extracellular signal-regulated kinase ½; FOXO: forkhead box protein O subclass; HMGB1: High mobility group box 1; IkB: Inhibitor of Nuclear factor B; IKK: Inhibitor of nuclear factor B kinase; JAK: Janus kinase; JNK: c-jun N-terminal kinase;  MAC-1: macrophage-1 antigen; NADPH: nicotinamide adenine dinucleotide phosphate;  NF kB: Nuclear factor kapa B; P38MAPK: Mitogen associated protein kinase P38; RAGE: receptor for Advanced glycation endproducts; ROS: reactive oxygen species; SAPK: stress-activated protein kinase; STAT: signal transducer and activator of transcription; TLR: Toll-Like Receptor.
See this image and copyright information in PMC

References

    1. Akirav EM, Preston-Hurlburt P, Garyu J, Henegariu O, Clynes R, Schmidt AM, Herold KC. 2012. RAGE expression in human T cells: a link between environmental factors and adaptive immune responses. PLoS ONE, 7, e34698. - PMC - PubMed
    1. Alleva LM, Yang H, Tracey KJ, Clark IA. 2005. High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99, 171–174. - PubMed
    1. Angeletti D, Kiwuwa MS, Byarugaba J, Kironde F, Wahlgren M. 2013. Elevated levels of High-Mobility Group Box-1 (HMGB1) in patients with severe or uncomplicated Plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene, 88, 733–735. - PMC - PubMed
    1. Arama C, Giusti P, Boström S, Dara V, Traore B, Dolo A, Doumbo O, Varani S, Troye-Blomberg M. 2011. Interethnic differences in antigen-presenting cell activation and TLR Responses in Malian children during Plasmodium falciparum malaria. PLoS ONE, 6, e18319. - PMC - PubMed
    1. Arama C, Maiga B, Dolo A, Kouriba B, Traoré B, Crompton PD, Pierce SK, Troye-Blomberg M, Miller LH, Doumbo OK. 2015. Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa? Acta Tropica, 146, 152–156. - PubMed

MeSH terms

Substances