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Observational Study
. 2016 Mar 25:17:35.
doi: 10.1186/s12882-016-0248-0.

KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods

Hee Gyung Kang  1 , Hyun Jin Choi  1 , Kyung Hee Han  2 , Seong Heon Kim  3 , Hee Yeon Cho  4 , Min Hyun Cho  5 , Jae Il Shin  6 , Joo Hoon Lee  7 , Joongyub Lee  8 , Kook Hwan Oh  9 , Young Seo Park  7 , Hae Il Cheong  1 , Curie Ahn  10 , Il-Soo Ha  11
Affiliations
Observational Study

KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods

Hee Gyung Kang et al. BMC Nephrol. .

Abstract

Background: The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children's growth and development. Therefore, an aggressive approach to preventing the progression of CKD and its complications is imperative. To improve the understanding and management of Asian pediatric patients with CKD, we designed and launched KNOW-Ped CKD (KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease), a nationwide, prospective, and observational cohort study of pediatric CKD with funding from the Korean government.

Methods/design: From seven major centers, 450 patients <20 years of age with CKD stages I to V are recruited for the comprehensive assessment of clinical findings, structured follow-up, and bio-specimen collection. The primary endpoints include CKD progression, defined as a decline of estimated glomerular filtration rate by 50 %, and a requirement for renal replacement therapy or death. The secondary outcomes include the development of left ventricular hypertrophy or hypertension, impairment of growth, neuropsychological status, behavioral status, kidney growth, and quality of life.

Discussion: With this study, we expect to obtain more information on pediatric CKD, which can be translated to better management for the patients.

Trial registration: NCT02165878 (ClinicalTrials.gov), submitted on June 11, 2014.

Keywords: Asian children; Chronic kidney disease; Cohort study; Design; Prognostic factor.

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References

    1. Kim S, Lim CS, Han DC, Kim GS, Chin HJ, Kim SJ, et al. The prevalence of chronic kidney disease (CKD) and the associated factors to CKD in urban Korea: a population-based cross-sectional epidemiologic study. J Korean Med Sci. 2009;24(Suppl):S11–21. doi: 10.3346/jkms.2009.24.S1.S11. - DOI - PMC - PubMed
    1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–305. doi: 10.1056/NEJMoa041031. - DOI - PubMed
    1. Feldman HI, Appel LJ, Chertow GM, Cifelli D, Cizman B, Daugirdas J, et al. The Chronic Renal Insufficiency Cohort (CRIC) Study: design and methods. J Am Soc Nephrol. 2003;14(7 Suppl 2):S148–53. doi: 10.1097/01.ASN.0000070149.78399.CE. - DOI - PubMed
    1. Imai E, Matsuo S, Makino H, Watanabe T, Akizawa T, Nitta K, et al. Chronic Kidney Disease Japan Cohort (CKD-JAC) study: design and methods. Hypertens Res. 2008;31(6):1101–7. doi: 10.1291/hypres.31.1101. - DOI - PubMed
    1. Levin A, Rigatto C, Brendan B, Madore F, Muirhead N, Holmes D, et al. Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) BMC Nephrol. 2013;14:121. doi: 10.1186/1471-2369-14-121. - DOI - PMC - PubMed

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