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. 2016 May;22(5):420-2.
doi: 10.1111/cns.12544. Epub 2016 Mar 25.

Caffeine Mitigates the Locomotor Hyperactivity in Middle-aged Low-density Lipoprotein Receptor (LDLr)-Knockout Mice

Jozimar C Szczepanik  1   2 , Paulo A de Oliveira  1 , Jade de Oliveira  2   3 , Josiel M Mack  1 , Daiane F Engel  3 , Daniel Rial  1 , Eduardo L G Moreira  2   4 , Andreza F de Bem  2   3 , Rui D Prediger  1   2
Affiliations

Caffeine Mitigates the Locomotor Hyperactivity in Middle-aged Low-density Lipoprotein Receptor (LDLr)-Knockout Mice

Jozimar C Szczepanik et al. CNS Neurosci Ther. 2016 May.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Genetic deletion of LDLr increases the locomotor activity in 3 m.o. mice as concluded from the total distance travelled (A and B), but does not interfere with the amount of time spent in the center of the open field (C). C57Bl/6 vehicle‐ (D) C57Bl/6 caffeine‐ (E), LDLr−/− vehicle‐ (F) and LDLr−/− caffeine‐ (G) treated mice display a similar thigmotaxic exploratory behavior. Data are expressed as mean ± SEM of 6–8 female mice per group. # P < 0.05 indicates a genotype effect (Newman‐Keuls post hoc test).
Figure 2
Figure 2
Genetic deletion of LDLr increases the locomotor activity, which was attenuated by chronic treatment with caffeine (10 mg/kg, p.o.) in 8 m.o. mice. Increased total distance travelled by LDLr−/− mice (A and B) but similar amount of time spent in the center (C). Similar thigmotaxic exploratory behavior between C57Bl/6 vehicle‐ (D) C57Bl/6 caffeine‐ (E), LDLr−/− vehicle‐ (F) and LDLr−/− caffeine‐ (G) treated mice. Data are expressed as mean ± SEM of 6‐8 female mice per group. *P < 0.05 compared to wt/vehicle group; # P < 0.05 compared to LDLr−/−/vehicle group (Newman–Keuls post hoc test).
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