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Comment
. 2016 May;26(5):515-6.
doi: 10.1038/cr.2016.41. Epub 2016 Mar 25.

Seeing is believing: Wnt3 localization in the gut epithelium

Alex Gregorieff  1 , Jeffrey L Wrana  1   2
Affiliations
Comment

Seeing is believing: Wnt3 localization in the gut epithelium

Alex Gregorieff et al. Cell Res. 2016 May.

Abstract

Wnt morphogens are notoriously elusive proteins. Thanks to a recent study published in Nature, Clevers and colleagues give us a first glimpse of a mammalian Wnt in action in the gut epithelium.

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Figures

Figure 1
Figure 1
Schematic view of the intestinal crypt and Wnt transfer from Paneth cells to intestinal stem cells (ISCs). (A) A gradient of Wnt activity subdivides the crypt into a stem cell zone composed of ISCs and Paneth cells at the crypt bottom and a transit-amplifying zone made up of progenitor cells. (B) Wnt secretion in Paneth cells depends partly on Porcupine and once released Wnts are captured by Frizzled receptors on ISCs. Frizzled turnover is mediated by Rnf43/Znrf3. The molecular mechanisms underlying Wnt secretion and transfer from Paneth cells to ISCs remain unclear.
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