Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 24;6(3):e010754.
doi: 10.1136/bmjopen-2015-010754.

Rehabilitation interventions in children and adults with infectious encephalitis: a systematic review protocol

Shanice Christie  1 , Vincy Chan  2 , Tatyana Mollayeva  3 , Angela Colantonio  3
Affiliations

Rehabilitation interventions in children and adults with infectious encephalitis: a systematic review protocol

Shanice Christie et al. BMJ Open. .

Abstract

Introduction: Many encephalitis survivors can benefit from rehabilitation. However, there is currently no comprehensive review describing rehabilitation intervention outcomes among children and adults with infectious encephalitis. This is a protocol for a systematic review that will summarise the current literature on outcomes following rehabilitative interventions among children and adults with infectious encephalitis. With a sufficient sample size, a sex-stratified analysis of the findings will also be presented, as variability between male and female patients with neurological disorders, including encephalitis, regarding outcomes after rehabilitative interventions has been noted in the literature.

Methods and analysis: This review will systematically search MEDLINE, MEDLINE In-Process, EMBASE, Cochrane Central Register of Controlled Trials, and PsycINFO using the concepts 'encephalitis' and 'rehabilitation'. Grey literature will be searched using Grey Matters: A practical search tool for evidence-based medicine and the Google search engine. In addition, reference lists of eligible articles will be screened for any relevant studies. 2 reviewers will independently evaluate the retrieved studies based on predetermined eligibility criteria and perform a quality assessment on eligible studies.

Ethics and dissemination: The results from this review hold the potential to advance our knowledge on the value of rehabilitative interventions targeting children and adults with infectious encephalitis and any sex differences among patients with regard to rehabilitative intervention outcomes. The authors will publish findings from this review in a peer-reviewed scientific journal (electronic and in-print) and present the results at national and international conferences.

Trial registration number: CRD42015029217.

Keywords: Infectious Encephalitis; Intervention; Non-Traumatic Brain Injury; Rehabilitation; Rehabilitation Outcome; Sex-Stratified Rehabilitation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Meningitis and encephalitis fact sheet: National Institute of Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/disorders/encephalitis_meningitis/detail_enceph... (accessed 15 Dec 2015).
    1. Association of American Medical Colleges. Infectious Disease, Internal Medicine 2015. https://www.aamc.org/cim/specialty/list/us/339608/infectious_disease_-in... (accessed 19 Nov 2015).
    1. George BP, Schneider EB, Venkatesan A. Encephalitis hospitalization rates and inpatient mortality in the United States, 2000–2010. PLoS ONE 2014;9:e104169 10.1371/journal.pone.0104169 - DOI - PMC - PubMed
    1. Khetsuriani N, Holman RC, Anderson LJ. Burden of encephalitis-associated hospitalizations in the United States, 1988–1997. Clin Infect Dis 2002;35:175–82. 10.1086/341301 - DOI - PubMed
    1. Kulkarni MA, Lecocq AC, Artsob H et al. . Epidemiology and aetiology of encephalitis in Canada, 1994–2008: a case for undiagnosed arboviral agents? Epidemiol Infect 2013;141:2243–55. 10.1017/S095026881200252X - DOI - PMC - PubMed

Publication types

LinkOut - more resources