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Comment
. 2016 Mar 25;351(6280):1398-9.
doi: 10.1126/science.aaf5542.

CANCER. The oncogene makes its escape

Jeremiah Wala  1 , Rameen Beroukhim  2
Affiliations
Comment

CANCER. The oncogene makes its escape

Jeremiah Wala et al. Science. .
No abstract available

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Figures

None
Chromatin architecture and gene expression.
(A) DNA has a hierarchical structure, with units of hundreds to thousands of kilobases organized into topologically associating domains (TADs). Smaller subdomains called insulated neighborhoods are organized by CTCF and cohesin binding at insulators. (B) Insulated neighborhoods provide protected units where genes can be co-regulated. (C) Otherwise well-behaved proto-oncogenes can become activated in cancer by disrupting the structure of insulated neighborhoods through deletions or mutations of boundary CTCF binding sites.
See this image and copyright information in PMC

Comment on

  • Activation of proto-oncogenes by disruption of chromosome neighborhoods.
    Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA. Hnisz D, et al. Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024. Epub 2016 Mar 3. Science. 2016. PMID: 26940867 Free PMC article.

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